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Experimental gene therapy enables children with inherited deafness to hear

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Gene therapy has successfully restored hearing in children born with inherited deafness. A recently published small study, conducted in China, revealed significant improvements in the hearing of five out of six children who underwent experimental gene therapy. The Children’s Hospital of Philadelphia also reported similar advancements in an 11-year-old boy, while earlier this month, Chinese researchers published a study demonstrating comparable results in two other children.

Currently, the experimental therapies focus on addressing a specific rare condition. However, scientists anticipate that similar treatments could eventually aid numerous children with various types of deafness caused by genetic factors. Globally, an estimated 34 million children experience deafness or hearing loss, with genetics contributing to up to 60% of cases. Hereditary deafness has become the latest target for gene therapy, already approved for treating conditions such as sickle cell disease and severe hemophilia.

Zheng-Yi Chen of Boston’s Mass Eye and Ear, a senior author of the study published in the Lancet on Wednesday, expressed excitement about the results: “No treatment could reverse hearing loss… That’s why we were always trying to develop a therapy.” Videos documenting the patients’ progress were captured by the research team. One video shows a baby, previously unable to hear, responding to a doctor’s words six weeks after treatment. Another depicts a young girl repeating words like father, mother, grandmother, sister, and “I love you” 13 weeks after treatment.

All the children in the experiments had a condition accounting for 2% to 8% of inherited deafness, caused by mutations in a gene responsible for an inner ear protein called otoferlin. The one-time therapy delivers a functional copy of that gene to the inner ear during a surgical procedure. The study, involving six children, took place at Fudan University in Shanghai, co-led by Dr. Yilai Shu. The therapy resulted in improved hearing in five out of six children, with no major side effects reported.

While the preliminary results from other research, including studies sponsored by Regeneron Pharmaceuticals and Eli Lilly’s subsidiary Akouos, have shown positive outcomes, questions remain regarding the long-term effectiveness of these therapies and the potential for continued improvement in the children’s hearing.

Despite the promising results, some ethical concerns surround gene therapy for deafness. Teresa Blankmeyer Burke, a deaf philosophy professor and bioethicist at Gallaudet University, emphasized the importance of engaging with the deaf community about the prioritization of gene therapy, considering its potential impact on the flourishing of signing Deaf communities.

Researchers remain optimistic about the progress of their work, with Chen stating, “This is real proof showing gene therapy is working. It opens up the whole field.” The development holds significant promise for the future treatment of various forms of genetic deafness in children.

Almost 80 years after the Holocaust, 245,000 Jewish survivors still living worldwide

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BERLIN. A recent report revealed that nearly 80 years after the Holocaust, approximately 245,000 Jewish survivors are still alive, residing in more than 90 countries. The data, disclosed on Tuesday, highlights the global distribution of survivors who have endured the atrocities of World War II.
The findings, presented by the New York-based Conference on Jewish Material Claims Against Germany, known as the Claims Conference, indicate that 49% of the survivors now live in Israel, while 18% are in Western Europe, 16% in the United States, and 12% in countries formerly part of the Soviet Union.
The demographic report, titled “Holocaust Survivors Worldwide: A Demographic Overview,” provides a detailed perspective on the current state of the survivors, with a median age of 86. Notably, 20% of them are older than 90, and a majority of survivors are women (61%) compared to men (39%).
Greg Schneider, the Claims Conference’s executive vice president, emphasized the significance of recognizing the individuals behind the statistics, stating, “These are Jews who were born into a world that wanted to see them murdered. They endured the atrocities of the Holocaust in their youth and were forced to rebuild an entire life out of the ashes of the camps and ghettos that ended their families and communities.”
The report classifies 96% of survivors as “child survivors” born after 1928, providing insight into the lasting impact of the Holocaust on those who experienced it.
Six million European Jews and individuals from other minorities fell victim to the Nazis and their collaborators during the Holocaust. The report acknowledges the difficulty in establishing the exact number of survivors, given the vast differences in pre-war and post-war Jewish populations across Europe.
In Poland, for instance, out of the 3.3 million Jews in 1939, only about 300,000 survived. Similarly, the Jewish population in Germany, which was around 560,000 in 1933, dwindled to about 15,000 by the end of World War II in 1945.
The demographic report also noted the resurgence of Germany’s Jewish community after 1990, with more than 215,000 Jewish migrants and their families arriving from the former Soviet Union, including survivors.
Today, Germany is home to 14,200 survivors, underscoring the ongoing impact of the Holocaust on the Jewish community. The Claims Conference, which manages compensation programs and advocates for survivors globally, plays a crucial role in ensuring support and acknowledgment for those who suffered during this dark chapter in history.
Gideon Taylor, the president of the Claims Conference, stressed the need for continued attention and care for the dwindling population of survivors, stating, “Now is the time to double down on our attention on this waning population. Now is when they need us the most.”
While the number of survivors diminishes with time, individuals like Ruth Winkelmann, a survivor in Berlin, persist in sharing their stories, fostering understanding, and urging future generations to unite against hatred and discrimination.

95-year-old Ruth Winkelmann, who is one of the survivors of the Holocaust, looks out of a window in Berlin, Germany, Wednesday, Jan. 17, 2024.(AP Photo/Ebrahim Noroozi)

This story was first published by AP

Kuwalipikadong government workers, pinag-aaplay ng grant sa additional points sa Civil Service Exam

Inihayag ng Civil Service Commission (CSC) ang kanilang pagsusulong sa Grant of Career Service Eligibility – Preference Rating (CSE-PR) sa mga kuwalipikadong manggagawa ng pamahalaan na may hindi bababa sa 10 taon ng serbisyong pampubliko, may karanasan at kaalaman ngunit walang angkop na civil service eligibility.

Batay sa CSC Resolution No. 2301123, ang Preference Rating na may maximum na 10 puntos ay idadagdag sa kasalukuyang rating (70.00 hanggang 79.99) upang maabot ang passing rate na 80.00 para sa Career Service Examinations (CSEs). Sa ganitong paraan, magiging kwalipikado ang mga aplikante para sa Career Service Professional o Subprofessional eligibility.

“In recognition of these government workers who have already contributed so much in our efforts to provide efficient public service, the CSC has resolved to grant them with CSE pre­ference rating under specific conditions,” ayon kay CSC Chairperson Karlo Nograles,

Ang mga interesadong makakuha ng CSE-PR ay inaanyayahang mag-apply at kumuha ng schedule para sa CSE simula sa ika-3 ng Marso 2024. Binigyang diin ni Chairperson Nograles na maaari lamang mag-avail ng isang beses ng CSE-PR grant ang bawat indibidwal.

Ipinapaabot ng CSC ang kanilang suporta sa mga naglilingkod sa pamahalaan na nagpupursigi na mapabuti ang kanilang kakayahan at serbisyong inilalaan sa publiko.

Provincial government of Laguna garners prestigious accreditation award from CSC

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QUEZON CITY, Metro Manila. Laguna Governor Ramil L. Hernandez led the delegation that proudly received the Accreditation Award bestowed by the Civil Service Commission (CSC). The award ceremony took place on 17 January 2024 at the CSC Resource Center Auditorium, Batasan Complex, during the Program to Institutionalize Meritocracy and Excellence in Human Resource Management (PRIME-HRM) Recognition Rites.

The prestigious award, granted through CSC Resolution No. 2301066, acknowledges the PGL’s exemplary management and implementation of its process-defined (Maturity Level 2) practices in Recruitment, Selection & Placement (RSP) and Performance Management (PM) under the PRIME-HRM framework.

Governor Hernandez expressed his gratitude and acceptance of the accolade during his acceptance speech. Provincial Administrator Atty. Dulce H. Rebanal, alongside Provincial Human Resource Management Officer Ms. Leah Teresa R. Javier, accepted the award on behalf of the Provincial Government. The award was presented by Commissioner Atty. Aileen Lourdes A. Lizada and Commissioner Atty. Ryan Alvin R. Acosta.

The recognition is a testament to the Provincial Government of Laguna’s commitment to promoting meritocracy and excellence in human resource management. The implementation of best practices in recruitment, selection, placement, and performance management has positioned PGL as a model for other entities to emulate.

The PGL expressed heartfelt appreciation to the CSC Field Office-Laguna, led by Director Charity F. Arevalo, and the CSC Regional Office IV, headed by Director Maria Leticia G. Reyna, for their unwavering support and invaluable assistance throughout the PRIME-HRM journey.

This Accreditation Award not only reflects the dedication and diligence of the Provincial Government of Laguna but also reinforces its commitment to fostering a work environment characterized by meritocracy, efficiency, and excellence. The recognition marks a significant milestone in the PGL’s ongoing pursuit of organizational development and administrative excellence.

Russia accuses Ukraine of downing military transport plane, killing 65 Ukrainian POWs

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Russia’s Defense Ministry made a grave accusation on Wednesday, claiming that Ukrainian forces shot down a military transport plane, resulting in the tragic death of all 74 individuals on board. Among the casualties were 65 Ukrainian prisoners of war who were intended for a swap.

The incident reportedly occurred in Russia’s Belgorod border region, although Ukrainian officials have yet to confirm or deny the claims made by Russia. The news broke during the Program to Institutionalize Meritocracy and Excellence in Human Resource Management (PRIME-HRM) Recognition Rites at the CSC Resource Center Auditorium in Batasan Complex.

The Associated Press could not independently verify the details of the incident, given the challenges of ascertaining facts in a war zone, where conflicting accusations are common, and information is tightly controlled by both sides.

Video footage circulating on social media depicted the aircraft plummeting from the sky in a snowy, rural area, followed by a massive explosion upon impact.

According to the Russian military, the Il-76 transport plane carried not only the 65 prisoners of war but also a crew of six and three other passengers. The Defense Ministry alleged that two missiles were launched from Ukraine’s Kharkiv region, bordering the Belgorod region, constituting what they referred to as a “terrorist act.”

Emergency services, including firefighters, ambulances, and police, promptly responded to the crash site in the Korochansky district of Belgorod, as reported by state news agency Tass.

The tragic event unfolded as part of a planned prisoner swap, with the aircraft en route from Chkalovsky airfield in the Moscow region to the Belgorod region. The exchange was scheduled to take place at the Kolotilovka crossing on the Russian-Ukrainian border.

Ukraine’s Kharkiv region and Russia’s Belgorod region have been focal points of the conflict, marked by long-range airstrikes, missiles, and drones.

In response to the crash, Ukraine’s Coordination Headquarters for the Treatment of Prisoners of War expressed a commitment to investigating the incident, cautioning against the dissemination of unverified information. The Russian Defense Ministry announced the dispatch of a special military commission to the crash site.

President Vladimir Putin’s spokesperson, Dmitry Peskov, refrained from commenting, citing a lack of information, while the Ukrainian military intelligence spokesman, Andrii Yusov, acknowledged the planned swap but sought verification regarding the involvement of Ukrainian POWs.

As the international community awaits further details on this tragic incident, tensions persist in the region amidst ongoing conflict, with both Russia and Ukraine actively engaged in military operations.

Christopher Nolan’s ‘Oppenheimer’ leads Oscar nominations, Greta Gerwig snubbed in Best Director category

NEW YORK. In the wake of a challenging year for the film industry marked by strikes and work stoppages, the Academy Awards announced their nominations on Tuesday, with Christopher Nolan’s biopic “Oppenheimer” leading the pack with 13 nominations.

Nolan’s three-hour epic, widely considered a frontrunner for Best Picture, received nods not only for the top honor but also for Nolan’s direction. Additionally, key cast members Cillian Murphy, Robert Downey Jr., and Emily Blunt earned acting nominations, while the film garnered recognition for its overall craftsmanship in depicting the J. Robert Oppenheimer drama.

Despite being recognized as a prominent filmmaker of his generation, Nolan has yet to win an Academy Award, and none of his previous films have secured the Best Picture accolade. Reflecting on the success of “Oppenheimer,” which combined a lengthy narrative with historical depth and grossed nearly $1 billion, Nolan expressed gratitude for the acknowledgment from the academy, stating, “It certainly confirms our faith in what studio filmmaking can be.”

Greta Gerwig’s feminist comedy “Barbie,” the highest-grossing film of the year, received eight nominations, including Best Picture, and acting nods for Ryan Gosling. However, Gerwig was notably absent from the Best Director category, a departure from her 2018 nomination for “Lady Bird.” The Best Director field has seen increased recognition for women in recent years, with Chloé Zhao and Jane Campion winning the award.

Other well-received films included Yorgos Lanthimos’ “Poor Things” and Martin Scorsese’s “Killers of the Flower Moon,” both receiving 11 and 10 nominations, respectively. Lily Gladstone, the star of “Killers of the Flower Moon,” made history as the first Native American nominated for Best Actress.

The Best Picture nominees comprised a diverse selection, with three films directed by women: “Past Lives” by Celine Song, “Anatomy of a Fall” by Justine Triet, and Gerwig’s “Barbie.”

In a surprising turn, the Best Actor category included Paul Giamatti, Jeffrey Wright, Bradley Cooper, and Colman Domingo, who became the second openly gay man nominated for playing a gay character. The Best Actress category featured nominees Lily Gladstone, Emma Stone, Carey Mulligan, Annette Bening, and Sandra Hüller, leaving out Margot Robbie and Fantasia Barrino.

Supporting actress Da’Vine Joy Randolph continued her strong awards season presence for “The Holdovers,” alongside other nominees including Emily Blunt, Danielle Brooks, Jodie Foster, and America Ferrera.

Notably, The Associated Press received its first Oscar nomination in its 178-year history for “20 Days in Mariupol,” a documentary chronicling the besieged Ukrainian city.

The Best Picture lineup reflected a balance between theatrical releases and streaming platforms, with Netflix leading with 18 nominations. The nominations indicated a return to the significance of theatrical releases, with Apple and Amazon prioritizing cinematic releases after acquiring MGM.

While the Oscars have historically favored smaller films, the nomination of “Oppenheimer” signals a potential shift, as the blockbuster grossed $326.8 million domestically and nearly $1 billion globally. The upcoming ceremony on March 10, hosted by Jimmy Kimmel, is expected to benefit from the presence of popular films like “Oppenheimer” and “Barbie.”

The Vatican’s top AI ethics expert is a friar from a medieval Franciscan order

ROME. Friar Paolo Benanti wears the plain brown robes of his medieval Franciscan order as he pursues one of the most pressing issues in contemporary times: how to govern artificial intelligence so that it enriches — and doesn’t exploit — people’s lives.

Benanti is the Vatican’s go-to person on the technology and he has the ear of Pope Francis as well as some of Silicon Valley’s top engineers and executives.

With a background in engineering, a doctorate in moral theology and a passion for what he calls the “ethics of technology,’’ the 50-year-old Italian priest is on an urgent mission that he shares with Francis, who, in his annual peace message for 2024, pushed for an international treaty to ensure the ethical use of AI technology.

“What is the difference between a man who exists and a machine that functions?” said Benanti in an interview this week with The Associated Press during a break at the Pontifical Gregorian University, where he teaches courses such as moral theology and bioethics to students preparing for the priesthood. “This is perhaps the greatest question of these times, because we are witnessing a challenge that every day grows more profound with a machine that is humanizing.”

Benanti is a member of the United Nations’ Advisory Body on Artificial Intelligence as well as head of an Italian government commission tasked with providing recommendations on how to safeguard journalism from fake news and other disinformation. He is also a consultant to the Vatican’s Pontifical Academy for Life.

Benanti says he helps “better clarify the more technical terms for the Holy Father” during their encounters. His knowledge came in handy for a 2023 meeting at the Vatican between Francis and Microsoft President Brad Smith that focused on how AI could help or hurt humanity.

Francis and Smith had also discussed artificial intelligence “at the service of the common good” during a meeting a few years earlier, according to the Vatican. With a papacy heavily attentive to those who live on society’s margins, Francis has made clear his concern that AI technology could limit human rights by, say, negatively impacting a homebuyer’s mortgage application, a migrant’s asylum bid or an evaluation of an offender’s likelihood to repeat a crime.

“It’s clear that if we choose some data that aren’t sufficiently inclusive, we will have some choices that aren’t inclusive,″ said Benanti, whose religious order was founded in the early 13th century by St. Francis of Assisi, who renounced earthly riches and promoted charitable works.

Microsoft first reached out to Benanti several years ago for his thoughts on technology, the friar said. In 2023, Smith did a podcast with Benanti in Rome, describing the friar as bringing “one of the most fascinating combinations in the world” in terms of his background in engineering, ethics and technology, to the AI debate.

Benanti, who was one year shy of obtaining his engineering degree at Rome’s Sapienza University when he forsook the degree — and also his girlfriend — to join the Franciscans in his 20s, described how AI could be a “really powerful tool” in bringing down the cost of medicine and empowering doctors to help more people.

But he also described the ethical implications of a technology that could have the same capabilities as a human — or perhaps even more.

“It is a problem not of using (AI) but it is a problem of governance,’’ the friar said. ”And here is where ethics come in — finding the right level of use inside a social context.”

Benanti noted that much of the data that informs AI is fed by low-wage workers, many in developing countries entrenched in a history of colonialism and an exploited workforce.

“I don’t want this to be remembered as the season in which we extract from the global South cognitive resources,” he said. If one examines “the best tools that we are producing in AI” in the West, one sees that AI is “trained with underpaid workers from English-speaking former colonies.″

How to govern AI is an issue that countries all over the globe are trying to resolve. The European Union became a trailblazer late last year when negotiators secured a deal that paves the way for legal oversight of AI technology.

In Italy, Premier Giorgia Meloni, who worries that AI could lead to job losses, will make the technology a focus of this year’s G-7 summit being hosted by Italy. As part of those efforts, Meloni on Thursday met with visiting Microsoft founder Bill Gates in Rome, an encounter that was attended by Benanti.

For his part, the friar told AP that regulating artificial intelligence shouldn’t mean limiting its development.

“It means keeping them compatible with that fragile system that is democracy, that today seems to be the best system,” Benanti said.

PBBM sa Comelec: “Bayad” na People’s Initiative signature campaign, ibasura

Nakataldang ipawalang-bisa ng Commission on Elections (Comelec) ang mga pirma sa People’s Initiative na nakuha kapalit ng pera.

“Well, pagka binayaran ‘yung signature, hindi tatanggapin ng Comelec ‘yun. So walang magandang mangyayari,” ayon kay Pangulong Ferdinand Marcos Jr., sa isang panayam matapos ang opisyal na paglulunsad ng Lung Transplant Program ng Lung Center of the Philippines (LCP) at National Kidney and Transplant Institute (NKTI) sa Quezon City.

Binasura naman ng Pangulo ang napaulat na signature-buying para sa naturang kampanya, sinabi niya na may napaulat na may ilang benepisyo na matatanggap para makaakit ng mga botante na pumirma. Itatanong aniya niya sa mga miyembro ng Kongreso kung tama ang napaulat na ito.

“So, ang pagkakaalam ko hindi naman, wala namang ganoon. Ang sinasabi hindi bayaran ng cash, kundi nangangako ng kung anu-anong benefits. Tinitignan namin, sabi ko, ‘itinanong ko sa ating legislation, totoo ba ‘yan?'” aniya pa rin.

Tinugunan din ng Chief Executive ang suhestiyon na suspendihin ng mga ahensiya ang kanilang social services programs upang hindi magamit sa pangangalap ng pirma para sa people’s initiative. Sinabi ng Pangulo na hindi niya magagawang pigilan o ihinto ang implementasyon ng kahit na anumang serbisyo lalo pa’t maraming mga Filipino ang nangangailangan ng tulong.

“Hindi naman nagbago yung mga release natin, constant pa din. Hindi naman maganda din ‘yun kasi may mga nangangailangan talaga,” ayon sa Chief Executive.

Sa halip aniya ay hayaan ang Comelec na gawin ang trabaho nito pagdating sa balidasyon ng mga pirma.

“We just let Comelec do their job and their work to validate the signature. And if there’s suspicion na may ganoon nga ay hindi talaga mabibilang ang mga signature na ‘yun,” ayon sa Pangulo.

Upang maikonsiderang mahalaga ang people’s initiative, ang bawat congressional district ay kailangan na makakalap ng pirma ng 3% ng registered voters nito.

PeekUp, the new game-changing ride-hailing app, enters the game in 2024

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In the bustling landscape of Metro Manila and surrounding cities, a revolutionary player is about to shake up the ride-hailing industry – introducing PeekUp, a game-changing service crafted by Filipinos for the Filipino commuter. Founded by Dave M. Almarinez, the CEO of A Force Ventures Inc., and Jayson Chua, the CFO, PeekUp is poised to redefine transportation by offering affordable, reliable, and convenient mobility solutions for both passengers and driver partners.

Scheduled for launch in the first quarter of 2024, PeekUp aims to address the transportation challenges that plague the daily lives of commuters in Metro Manila and nearby areas. With the commitment to accommodate passengers during high peak hours, PeekUp ensures a safe and reliable journey with ride options like PeekUp Compact 4-Seater, PeekUp Taxi, and PeekUp Plus 6-Seater.

Booking a ride has never been easier – users can seamlessly navigate the intuitive and user-friendly PeekUp App, available for free download. The app leverages state-of-the-art technology, providing real-time tracking, a sleek interface, and advanced safety features, making it a go-to choice for commuters seeking a stress-free experience.

PeekUp takes pride in its commitment to transparency and fairness. Dynamic pricing adapts to demand, ensuring budget-friendly rates without compromising service quality. Passengers can review the ride-cost breakdown, aligning with PeekUp’s transparency policy and creating a mutually beneficial ecosystem for both users and partner-drivers.

Safety remains paramount at PeekUp, with rigorous partner-driver screening processes, real-time ride monitoring, and emergency response features to guarantee a secure environment for all users. Dave M. Almarinez emphasizes PeekUp’s dedication to alleviating the frustrations and challenges faced by Filipino commuters, aiming to revolutionize transportation by offering reliable and affordable mobility options.

“We understand the deep frustration and longstanding challenges of the Filipino commuter, and we believe that we can help alleviate their woes and revolutionize the transportation landscape by offering more reliable and affordable mobility options. We believe that we’re entering the industry at a very opportune time and we are thrilled to introduce PeekUp to Metro Manila and beyond. Our team has worked tirelessly to create a ride-hailing platform that combines cutting-edge technology with a sincere commitment to convenience, safety, fairness, and community engagement. PeekUp is here not just to provide you a ride; we’re here to bring you a seamless, stress-free experience,” says Almarinez.

Join PeekUp on the journey towards a smarter, safer, and seamless mobility future. The platform is set to launch in Metro Manila, Laguna, Cavite, Rizal, Bulacan, and nearby cities in Q1 2024. To learn more and sign up for early access, visit www.peekup.net. Soon, you can also download the PeekUp App via the Apple Store and Google Play. Don’t miss the chance to be part of the PeekUp revolution!

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Iniimbestigahan ang 13 ang persons of interest sa pagpatay sa barangay chairman sa Laguna

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CALAMBA CITY, Laguna. Tinukoy ng Special Investigation Task Group “Cogay” ang 13 indibiduwal bilang mga persons of interest kaugnay sa brutal na pagpatay kay Mario Jun Cogay, ang acting barangay chairman ng Canlubang sa lungsod na ito.

Ayon sa pahayag ni Police MSgt Jayson Paguio, isang imbestigador mula sa Calamba, kabilang sa mga ipinatawag ang apat na security ni Cogay, ang walong elected barangay councilmen, at ang hindi pa opisyal na proklamadong nanalong chairman na si Larry Dimayuga.

Nakapagbigay na ng affidavit ang 13 persons of interest sa task group, ayon kay Paguio.

Sa mensahe ni Laguna police director Col. Harold Depositar, nakalap ng Laguna PNP ang 60 kopya ng CCTV footages, at apat sa mga ito ang naeksamin na. “We are still conducting backtracking investigation and crime mapping sa crime site at doon nakita sa camera ang mga suspects na nakasakay sa motorsiklo,” pahayag ng mga imbestigador.

Ayon sa mga awtoridad, posibleng miyembro ng gun-for-hire syndicate at mga professional hitman ang mga pumatay kay Chairman Cogay dahil sa istilo at bilis ng execution na kanilang ginawa.

Nanawagan ang pamilya ni Cogay sa mga opisyal ng PNP Calabarzon para sa agarang resolusyon ng kaso at para mapanagot sa korte ang mga nasa likod ng pagpatay sa kanilang mahal sa buhay.

Si Cogay ay pinagbabaril noong Sabado ng madaling araw ng mga armadong kalalakihan habang nasa gate ng kanyang bahay sa Canlubang.

Samantalang, nag-alok ng kalahating milyong pisong pabuya si Calamba City Mayor Ross Rizal para sa sinumang makapagtuturo sa mga suspects sa likod ng nasabing krimen.