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Pancreatic cancer vaccine shows promise in small initial trial

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An mRNA vaccine prevented tumor recurrence after surgery in eight of 16 patients, but the therapy still needs to be validated in larger trials

Pancreatic cancer is one of the deadliest forms of cancer, with very few effective treatments. But messenger RNA (mRNA) vaccines—famous for their ability to prevent COVID—are starting to show some promise against the lethal cancer. In a recent early-stage trial, half of pancreatic cancer patients who received a personalized mRNA cancer vaccine after surgery did not have a recurrence of the tumor a year and a half later. The trial, which was described in a study published on Wednesday in Nature, was small—with just 16 patients—and it will need to be replicated in larger studies.

“I am very supportive of the findings,” says Drew Weissman, director of vaccine research and director of the Institute for RNA Innovation at the University of Pennsylvania, who is a pioneer of mRNA vaccines but was not involved in the new paper. He adds that “it is not a definitive proof-for-use study. Larger studies are needed to determine effectiveness.”

Pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, has a mortality rate of 88 percent. It is the third leading cause of death from cancer in the U.S. and is becoming more common. Surgery is the main form of treatment, but the cancer has a 90 percent recurrence rate at seven to nine months. Chemotherapy is only partially effective at delaying recurrence. Other treatments, such as immunotherapy, are mostly ineffective.

Pancreatic cancer often goes undetected until its later stages, when it is harder to treat. One reason it is so sneaky is that it generates relatively few of a type of surface proteins, called neoantigens, that mark it as foreign and trigger an immune response. Scientists had noticed that people who survived pancreatic cancer had a stronger response to these neoantigens from T cells, a type of immune cell.

In the new study, Vinod Balachandran, an assistant attending surgeon at Memorial Sloan Kettering Cancer Center in New York City, and his colleagues targeted pancreatic cancer patients’ own tumor neoantigens using mRNA technology—the same technology used to create the remarkably successful COVID vaccines. The experimental vaccines used by Balachandran and his colleagues were produced by BioNTech, a company that developed one of the COVID vaccines with Pfizer. The researchers vaccinated a total of 16 patients. After surgically removing the tumors, they treated the patients with mRNA vaccines tailored to each person’s specific cancer, as well as an adjuvant, a substance that increases the effects of vaccines. Fifteen of the participants were also treated with chemotherapy.

Eight of the 16 patients generated a strong T cell response to the vaccines. At a median follow-up time of 18 months after the treatment, these individuals had longer survival, without a recurrence of their cancer.

The study was small and involved only white patients. And the therapy—which is expensive—does not work for everyone with pancreatic cancer. Nevertheless, experts say it is a promising development for a disease with such limited treatment options.

Opisina ni Quezon Governor Helen Tan, nilooban

Gumaca, Quezon. Nilooban at ninakawan ang satellite office ni Quezon Governor Helen Tan sa Brgy. Tabing Dagat sa bayang ito, kamakalawa, ayon sa mga ulat ng pulisya.

Nadiskubre ng isang tauhan ni Tan ang pangyayari, bandang alas-7:00 ng umaga, at natuklasan nilang sinira ng mga suspek ang padlock ng pinto ng opisina.

Sinira rin ng mga magnanakaw ang metal na kabinet at kinuha ang hindi tinukoy na halaga ng pera kasama ang laptop at isang CCTV monitor.

Batay sa imbestigasyon, natuklasan na pinutol ng mga hindi pa kilalang suspek ang kable ng CCTV monitor upang itago ang kanilang pagnanakaw.

Patuloy na nagsasagawa ng imbestigasyon ng mga awtoridad sa insidente upang matukoy ang mga suspek sa krimen na ito.

Nag-anunsyo ang mga fuel firms ng pagtaas ng presyo ng langis

Inaasahan ng mga motorista ang mas mataas na presyo ng mga produktong petrolyo simula ngayong araw ng Martes, ayon sa mga kumpanya ng langis.

Sa magkahiwalay na abiso, nag abiso ang SeaOil, Caltex, Jetti, UniOil, Phoenix Petroleum, at PTT Philippines sinabi na tataas ng ₱0.35 kada litro ng gasolina.

Ang presyo naman ng diesel ay tataas ng ₱1.40.

Sinabi rin ng SeaOil at Caltex na ang presyo ng kerosene ay tataas ng ₱1.20 kada litro.

Ayon sa obserbasyon, tumaas ng ₱4.20 kada litro ang presyo ng gasolina hanggang May 15.

Thai election: Who is Pita Limjaroenrat, the Move Forward Party leader

“Today is a new day, and hopefully it is full of bright sunshine and hope,” 42-year-old Pita Limjaroenrat told a room packed with reporters and flashing cameras, hours after it had become clear that he could well be Thailand’s next prime minister.

Mr Pita’s party, Move Forward, which in Thai evokes leaps of change, has swept to a surprising and stunning victory. Voters rejected nearly a decade of army-backed rule, handing more seats and votes to Move Forward than any other party. That is is no mean achievement in a country that has experienced at least a dozen successful coups.

“The sentiment of the era has changed. And it was the right timing,” Mr Pita said, speaking at the party’s headquarters in Bangkok, where it had won 32 of the city’s 33 seats.

The business of forming a government is still weeks away. It can also get messy, given that Thailand’s military still has the power to play kingmaker. But the win has put the spotlight on Mr Pita and his party, who have built a strong following among young voters disillusioned by years of military rule and hungry for change.

Mr Pita started his political career when he was elected to parliament in 2019 as a member of the Future Forward Party. Founded by Thanathorn Juangroongruangkit, a billionaire and staunch critic of the army, the party performed well in the 2019 election, shaking up Thai politics with its demand for change.

But Future Forward was forced to disband, the following year in the wake of contentious allegations. And Mr Thanathorn was disqualified as an MP. Move Forward was formed soon after as its successor and named Mr Pita its new leader.

Thousands of young people took to the streets in Thailand that year after the ban, demanding amendments to the constitution, a new election and an end to the harassment of rights activists and state critics. That desire for change and many of those very issues drove Move Forward’s appeal in this election, with some of the protest leaders from 2020 running as candidates.

Mr Pita – once called a “rising star” of the Thai parliament because of the critical speeches he made as an opposition MP – also gained popularity with his party’s bold promises to break the military’s political influence and reform laws relating to the monarchy.

Move Forward will continue to push forward lèse-majesté reforms, Mr Pita reiterated on Monday. “We will pass that in this parliament. And we will use the parliament to make sure that it is a comprehensive discussion with maturity, with transparency, in how we should move forward in the relationship between the monarchy and the masses,” he added.

Mr Pita was born to a wealthy Thai family with political connections. His father was an adviser in the agriculture ministry and his uncle was an aide of former ousted PM Thaksin Shinawatra.

He has said he developed an interest in politics during his high school days in New Zealand.

“I got shipped to the middle of nowhere in New Zealand and there were three [TV] channels back then. Either you watch Australian soap operas, or you watch the debates in parliament,” he told the Thai YouTube programme Aim Hour in February this year.

He graduated with a bachelor’s degree in finance in Bangkok’s Thammasat University, a master’s in public policy from Harvard University and an MBA from the Massachusetts Institute of Technology.

But he started his career in business, first taking over the running of his late father’s rice bran oil company and later as an executive director of ride-hailing company Grab.He was married to Chutima Teenpanart, a Thai actress-model, but the couple divorced in 2019. He is now a single dad of seven-year-old Pipim, whom he has brought to Move Forward’s rallies. (with reports from BBC)

Itinigil ng Kuwait ang pag-iisyu ng mga entry visa para sa mga Pilipino

Itigil ng Kuwait ang pag-isyu ng mga bagong visa para sa mga Pilipino, ayon sa ulat ng Kagawaran ng Ugnayang Panlabas (DFA) noong Biyernes.

Sinasabing ito ay dahil sa hindi pagsunod ng Pilipinas sa isang labor agreement  ng dalawang bansa, subalit hindi tinukoy ng interior ministry ng Kuwait ang partikular na seksyon sa kasunduan na nilabag ng Pilipinas, ayon sa DFA.

Inanunsiyo ng DFA na agad na magiging epektibo ang pagpapahinto sa pag-iisyu ng visa na iiral  “until further notice.”

Umaasa ang DFA na malulutas ang isyung ito. “… We are confident that with our friendly relations and strong people-to-people links, we shall be able to find a mutually satisfactory solution that will take into account the need to provide maximum protection and access to justice for all our nationals working in the country,” ayon dito.

Ang mga Pilipinong babalik mula sa Kuwait ay makakatanggap ng tulong mula sa DFA, Department of Migrant Workers (DMW), at Overseas Workers Welfare Administration (OWWA). May mga spekulasyon na ang pagpapahinto sa pag-iisyu ng visa ay bilang pagsalungat sa pagbabawal ng Pilipinas sa pagpapadala ng mga bagong manggagawa sa Kuwait matapos ang pagpatay sa 35 anyos na si Jullebee Ranara sa kamay ng anak ng kanyang amo.

Dahil dito, sinuri ng mga senador ng Pilipinas ang labor agreement ng dalawang bansa na pumapabor sa mga karapatan ng mga OFW, na nilagdaan noong 2018 matapos ang pagkamatay ni OFW Joanna Demafelis.

Sinabi ni Foreign Affairs Undersecretary Eduardo de Vega sa isang panayam sa radyo noong Biyernes na pinag-uusapan na nila ang pag-alis ng ban sa deployment, ngunit kailangan pa nilang talakayin ito sa iba pang kinauukulan ahensya ng pamahalaan.

Mayroong 268,000 Pilipino na naninirahan at nagtatrabaho sa Kuwait.

Sinabi ng DMW noong Biyernes na handa itong tumulong sa mga OFW na naapektuhan ng desisyon ng Kuwait na itigil ang pag-iisyu ng visa para sa mga Pilipino.

Patuloy umanong isusulong ng DMW ang labor diplomacy  upang tiyakin ang kagalingan at kaligtasan ng mga OFW, habang hinihintay ang karagdagang mga detalye mula sa pamahalaan ng Kuwait.

Hinihikayat ang mga apektadong OFW patungo sa Kuwait na makipag-ugnayan sa DMW sa pamamagitan ng National Reintegration Center for OFWs (NRCO) sa hotlines na 09567821309 at 09603532532 o mag email sa nrco@dmw.gov.ph.

“We assure everyone that the DMW will work with all of its partners to mitigate the impact of this recent development to our Kuwait-bound workers,” dagdag pa ng DMW.

Pilipinas naglalagay ng buoy sa  South China Sea upang igiit ang soberanya

Maynila. Naglalagay ang Pilipinas ng mga navigational buoy sa loob ng exclusive economic zone (EEZ) nito upang ipahayag ang soberanya sa pinag-aagawang Spratly Islands sa South China Sea, ayon sa salaysay  ng tagapagsalita ng coast guard noong Linggo (Mayo 14).

Ang hakbang na ito ay kasunod ng lumalalang kilos ng China sa  South China Sea habang isinusulong ni Pangulong Ferdinand Marcos Jr ang mas mahigpit na ugnayan sa kaalyadong Estados Unidos.

Sinabi ng Philippine Coast Guard na naglagay sila ng limang buoy na may bandila ng Pilipinas mula Mayo 10 hanggang Mayo 12 sa limang lugar sa loob ng 322 km na zone, kasama ang Whitsun Reef kung saan nagbabanggaan ang daan-daang barkong pandagat ng China noong 2021.

“Ipinapakita ng hakbang na ito ang matibay na determinasyon ng Pilipinas na pangalagaan ang kanyang mga hangganan at yaman sa karagatan at bilang pagkilos para sa kaligtasan ng kalakalang pandagat,” ayon sa post sa Twitter ni Commodore Jay Tarriela, ang tagapagsalita ng coast guard sa mga South China Sea issues.

Hindi agad sumagot ang embahada ng China sa Manila sa kahilingan sa pahayag.

Noong Mayo 2022, naglagay din ang coast guard ng limang navigational buoy sa apat na isla sa Spratlys.

Ang pahayag ng China na mayroon itong soberanya sa halos buong South China Sea ay ibinasura ng isang international arbitration ruling nong 2016.

Ang Brunei, Malaysia, Taiwan, at Vietnam ay naghahabol din ng pagmamay ari sa Spratlys, kung saan nagtambak ng buhangin ang China upang magtayo ng mga isla sa mga bahura at naglagay dito ng mga missile at runway.

Sa loob ng mga taon, nagpadala ang Beijing ng daan-daang barkong pandagat at pangingisda sa mga pinagtatalunang lugar.

Trahedya sa Lipa: Estudyante, patay sa banggaan ng motorsiklo

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Lipa City, Batangas. Isang estudyante ang namatay matapos maaksidente ang kanyang motorsiklo na bumangga sa isa pang motorsiklo habang pareho silang naglalakbay sa iisang linya ng kalsada, kagabi ng madaling araw, sa Brgy. Tambo sa lungsod na ito.

Batay sa ulat ng Lipa City Police Station, kinilala ang biktima na si Jonathan Bautista na residente ng Brgy. Nangkaan, Mataas na Kahoy, Batangas. Samantala, sugatan naman si Joshua Alex Lumbera, 24 anyos na call center agent at residente ng Brgy. San Carlos.

Bandang alas-12:05 ng madaling-araw, habang naglalakbay ang dalawang motorsiklo sa J.P Laurel Highway patungo sa city proper noong nangyari ang insidente. Si Bautista ay nagmamaneho ng isang NMax na motorsiklo habang si Lumbera ay sakay ng isang Mio. Sa isang kurbada ng kalsada, pareho silang nawalan sila ng kontrol at nagbanggaan.

Namatay si Bautista dahil sa malalang sugat sa ulo at iba’t ibang bahagi ng katawan. Dinala agad siya Lipa City District Hospital ngunit idineklara dead on arrival. Samantala, si Lumbera ay nagtamo ng mga minor na sugat at kasalukuyang ginagamot.

Ayon sa mga ulat ng pulisya, maaaring magkaroon ng amicable settlement sa pagitan ng dalawang partido sa aksidenteng ito.

Powerful cyclone Mocha hits Myanmar, leaving destruction and casualties

DHAKA, Bangladesh. Thousands sought refuge in monasteries, pagodas, and schools as Cyclone Mocha battered the coast of Myanmar, causing severe damage and claiming at least three lives. The cyclone made landfall in Myanmar’s Rakhine state near Sittwe township on Sunday afternoon, with wind speeds reaching up to 209 kilometers (130 miles) per hour, according to Myanmar’s Meteorological Department. Prior to reaching Myanmar, the storm passed over Bangladesh’s Saint Martin’s Island, causing injuries and damage but veered away from the country’s shores before making landfall.

As night fell, the extent of the damage in Sittwe remained uncertain. Earlier in the day, high winds toppled cell phone towers, resulting in communication disruptions across the area. Videos captured before the communication cutoff showed streets inundated with water and trees being lashed by strong winds, tearing off rooftops.

Reports from Rakhine-based media indicated that streets were flooded, trapping residents in low-lying areas, while concerned relatives outside the township appealed for rescue. Myanmar’s military information office stated that the storm damaged houses, electrical transformers, cell phone towers, boats, and lampposts in Sittwe, Kyaukpyu, and Gwa townships. Additionally, sports buildings on Coco Islands, located about 425 kilometers (264 miles) southwest of Yangon, suffered roof damage.

Over 4,000 residents, out of Sittwe’s population of 300,000, were evacuated to other cities. More than 20,000 people sought shelter in sturdy structures such as monasteries, pagodas, and schools situated in elevated areas of the city, according to Tin Nyein Oo, a volunteer in Sittwe’s shelters. However, the influx of people exceeded expectations, leading to insufficient food supplies in the shelters, as noted by Lin Lin, the chairman of a local charitable foundation.

Titon Mitra, the U.N. Development Program representative in Myanmar, expressed concerns about the situation, tweeting: “Mocha has made landfall. 2m people at risk. Damage and losses are expected to be extensive. We are ready to respond and will need unhindered access to all affected communities.” Myanmar state television reported that the military government was preparing to dispatch food, medicine, and medical personnel to the affected areas. After striking Rakhine, the cyclone weakened and was predicted to hit the northwestern state of Chin and central regions on Monday.

In Myanmar, several fatalities resulting from wind and rain were reported on Sunday. A rescue team from the eastern Shan state announced on Facebook that they had recovered the bodies of a couple who were buried in a landslide triggered by heavy rain in Tachileik township. Local media also reported a man’s death in Pyin Oo Lwin township in the central Mandalay region when a banyan tree fell on him.

Authorities in Cox’s Bazar, Bangladesh, previously in the predicted path of the storm, had evacuated hundreds of thousands of people. However, by early afternoon, it appeared that the country would mostly escape the storm as it veered eastward, stated Azizur Rahman, director of the Bangladesh Meteorological Department in Dhaka. He reassured reporters that the level of risk had significantly reduced in Bangladesh.

Although strong winds and rain persisted in Saint Martin’s Island in the Bay of Bengal, feared tidal surges did not occur due to the cyclone crossing the Bangladesh coast at low tide, according to Dhaka-based Jamuna TV station. Around a dozen islanders were injured, and approximately 300 homes were either destroyed or damaged, as reported by Bengali-language daily Prothom Alo.

Women spend time with their children at a makeshift shelter set up for residents of coastal areas, in Teknaf, near Cox’s Bazar, Bangladesh, Sunday, May 14, 2023. Bangladesh and Myanmar braced Sunday as a severe cyclone started to hit coastal areas and authorities urged thousands of people in both countries to seek shelter. (AP Photo/Al-emrun Garjon)

Mother’s Day in the Philippines: Honoring the Ilaw ng Tahanan

Mother’s Day is celebrated in numerous countries across the globe. (Not all countries observe Mother’s Day on the same date.) It is a special occasion when children express their love and appreciation for their mothers through cards, gifts, and flowers. Families come together on this day, allowing mothers to enjoy a day of rest while being taken care of by their husbands and children.

Filipinos hold their celebrations in high regard. Mother’s Day in the Philippines is a momentous occasion, and Filipinos approach their celebrations with utmost seriousness and dedication.

Mother’s Day carries profound significance here in the Philippines. This is primarily because of the prominent role mothers have in Filipino culture and their profound impact on the lives of their children.

Mothers are bestowed with the title “ilaw ng tahanan,” which translates to “light of the house” in English. This title acknowledges the warmth, generosity, and guiding presence that mothers bring to their families. It’s a perfect way to describe moms.

That’s why Mother’s Day goes beyond celebrating mothers alone; it’s a comprehensive celebration aimed at showing respect and gratitude to grandmothers, aunts, cousins, and other women in the family who are also mothers.

So, if you wish to incorporate Filipino tradition into your household, be sure to extend your appreciation to all your lolas (grandmothers), ninangs (godmothers), and tiyas (aunts) as well.

Historical Roots of Mother’s Day Celebrations

Ancient Greece celebrated a form of Mother’s Day, paying tribute to Rhea, the mother of the gods. Meanwhile, in Britain, an annual celebration known as Mothering Sunday emerged in the 1600s. This tradition arose from the circumstances of that time when many individuals lived away from home, working for their employers. On the fourth Sunday of Lent, they were encouraged to return home and visit their mothers. Along the way, they would gather flowers as gifts or offer cakes.

In the late 1800s, Julia Ward Howe, renowned for penning the ‘Battle Hymn of the Republic,’ was deeply disturbed by the devastation caused by the American Civil War. She introduced the concept of a ‘Mother’s Day for Peace,’ to be observed on June 2nd. However, enthusiasm for this idea waned when Howe was no longer able to fund the celebrations, and she redirected her efforts elsewhere.

The Journey of Mother’s Day: From Anna Jarvis to International Recognition

During the late 19th century and early 20th century, a remarkable woman named Anna Jarvis embarked on a mission to shed light on the inadequate health conditions in her community. Recognizing the immense support that mothers could provide, she named the day ‘Mothers Work Day.’ Sadly, Anna Jarvis passed away in 1905, but her daughter, also named Anna, took up the torch to honor her mother’s life and work.

Driven by a deep desire to commemorate her mother’s legacy, Anna Jarvis wrote heartfelt letters to politicians and businessmen, urging them to endorse a dedicated day for mothers. Specifically, she proposed that this special day should coincide with the anniversary of her mother’s passing. After relentless advocacy, President Woodrow Wilson finally proclaimed in 1914 that the second Sunday in May would be officially dedicated to honoring the “mothers of our country.”

As time went on, Mother’s Day gained recognition and appreciation beyond national borders. By the end of Anna Jarvis’ life, this cherished occasion was celebrated in more than 40 countries, symbolizing the universal gratitude and reverence for mothers worldwide.

3 Patay, 4 sugatan sa magkakahiwalay na pamamaril sa Quezon

LUCENA City, Quezon. Sa loob ng wala pang isang linggo, naganap ang apat na magkakasunod na kaso ng pamamaril ng riding-in-tandem sa lalawigan ng Quezon, kung saan tatlo ang namatay at apat ang sugatan.

Ang unang insidente ay nangyari sa Brgy. Mayao Castillo, Lucena City, kung saan binaril ng mga salarin ang isang 42-anyos na lalaki at ang kanyang 12-anyos na anak na babae habang sakay sila ng tricycle papunta sa eskwelahan noong Lunes ng umaga. Agad namatay ang ama sa lugar ng insidente habang dinala naman ang bata sa ospital subalit binawian rin ng buhay.

Noong Miyerkoles, isa pang biktima, isang 48-anyos na lalaki na residente ng Barangay Isabang sa Lucena City, ay binaril at napatay din ng riding-in-tandem habang pauwi mula sa paghahatid sa kanyang anak sa eskwelahan. Ang insidente ay naganap malapit sa gate ng kanilang tinitirhan na subdivision.

Noong Huwebes naman ng gabi, binaril ng riding-in-tandem ang isang 28-anyos na construction worker habang naglalakad sa gilid ng highway sa Brgy. Ibabang Iyam, Lucena City. Tinamaan din ng mga ligaw na bala ang isang driver na nagkataong kumakain sa isang karinderya malapit sa lugar. Dalawang tao ang nakaligtas at dinala sa ospital.

Sa bayan naman ng Tiaong, Quezon, nasugatan ang mag-asawang senior citizen na residente ng Brgy. Cabay nang barilin ng riding-in-tandem suspect sa national highway sa Sitio Centro, Brgy. Del Rosario habang sakay sila ng tricycle at papauwi sa kanilang tahanan noong Huwebes ng hapon ng alas 3:30. Nakaligtas ang mag-asawa sa pamamaril.

Nalaman na ang mister ay kakalabas lamang ng piitan noong Mayo 9 matapos maaresto ng CIDG Laguna PFU dahil sa kasong illegal possession of firearm noong April 28, 2023.

Pawang nakatakas ang mga salarin sa lahat ng apat na insidente. Patuloy pa rin ang imbestigasyon ng mga awtoridad sa mga sunod-sunod na pamamaril na ito.